| Date/Time | Away | Home | Line | ||||
|---|---|---|---|---|---|---|---|
| Byes: none | |||||||
| 1. | Sun, Sep. 19,1:00 PM | St. Louis (1-0) | 17 | 34 | Atlanta (1-0) | -2.5 (46) | |
| 2. |
|
Pittsburgh (1-0) | 13 | 30 | Baltimore (0-1) | -4 (36) | |
| 3. |
|
Houston (0-1) | 16 | 28 | Detroit (1-0) | -3 (43.5) | |
| 4. |
|
Chicago (0-1) | 21 | 10 | Green Bay (1-0) | -9 (41) | |
| 5. |
|
Denver (1-0) | 6 | 7 | Jacksonville (1-0) | +3 (39.5) | |
| 6. |
|
Carolina (0-1) | 28 | 17 | Kansas City (0-1) | -6 (46.5) | |
| 7. |
|
San Francisco (0-1) | 27 | 30 | New Orleans (0-1) | -7 (42) | |
| 8. |
|
Washington (1-0) | 14 | 20 | N.Y. Giants (0-1) | +3 (41) | |
| 9. |
|
Indianapolis (0-1) | 31 | 17 | Tennessee (1-0) | -1.5 (46.5) | |
| 10. | Sun, Sep. 19,4:05 PM | Seattle (1-0) | 10 | 6 | Tampa Bay (0-1) | +3 (37) | |
| 11. | Sun, Sep. 19,4:15 PM | New England (1-0) | 23 | 12 | Arizona (0-1) | +8 (42) | |
| 12. |
|
Cleveland (1-0) | 12 | 19 | Dallas (0-1) | -4 (39) | |
| 13. |
|
Buffalo (0-1) | 10 | 13 | Oakland (0-1) | -3.5 (38) | |
| 14. |
|
N.Y. Jets (1-0) | 34 | 28 | San Diego (1-0) | +3 (45.5) | |
| 15. | Sun, Sep. 19,8:30 PM | Miami (0-1) | 13 | 16 | Cincinnati (0-1) | -4.5 (39) | |
| 16. | Mon, Sep. 20,9:00 PM | Minnesota (1-0) | 16 | 27 | Philadelphia (1-0) | -3.5 (48.5) | |
All times are Eastern Standard Time.